2. Signaling Pathways
  3. Immunology/Inflammation
  4. NO Synthase

NO Synthase

Nitric oxide synthases; NOS

NO Synthase

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Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO synthases catalyze the oxidation of L-arginine to NO and L-citrulline. Mammals contain three NOS isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). NO produced from these different NOS isoforms is involved in a wide range of physiologic functions in the nervous, immune, and cardiovascular systems. Unregulated NO production can lead to pathologic conditions such as stroke, inflammation, and hypertension. Therefore, the control of NOS activity by isoform selective NOS inhibitors has great potential for therapeutic treatments of NO-related diseases.

NO Synthase Isoform Specific Products:

NO Synthase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-163888
    NO-IN-1
    		Inhibitor
    NO-IN-1 (Compound 7a) inhibits the production of NO (IC50 = 3.13 μΜ). NO-IN-1 has anti-inflammatory effects. NO-IN-1 downregulates the expression of COX-2 and iNOS by inhibiting the NF-κB signaling pathway.
    NO-IN-1
  • HY-115916
    NOS-IN-2
    		Inhibitor
    NOS-IN-2 (Compound 4i) is a potent, selective, imidamide derived NOS inhibitor with an IC50 against iNOS of 20 µM, without inhibiting eNOS. NOS-IN-2 has little toxicity and can be used for studying inflammatory disorders.
    NOS-IN-2
  • HY-N19122
    Pulchinenoside K
    		Inhibitor
    Pulchinenoside K (Compound 4) is a triterpenoid saponin. Pulchinenoside K can be isolated from the roots of *Pulsatilla koreana*. Pulchinenoside K inhibits NO production. Pulchinenoside K can be used for the research of inflammatory diseases.
    Pulchinenoside K
  • HY-105407
    GW 273629
    		Inhibitor
    GW 273629 is a selective nitric oxide synthase inhibitor. GW 273629 exhibits anti-inflammation effect.
    GW 273629
  • HY-N15504
    Cycloneroside C
    		Inhibitor
    Cycloneroside C is a novel sesquiterpene aminoglycoside compound discovered from the deep - sea - sediment fungus Trichoderma sp. SCSIOW21. Cycloneroside C has the activity of inhibiting the production of NO. In the experiment with macrophage RAW 264.7 cells, its IC50 value for inhibiting the production of NO is 57.1 μM. Cycloneroside C can be used in the research of the anti - inflammatory field.
    Cycloneroside C
  • HY-B1640A
    Ethacrynic acid sodium
    		Inhibitor
    Ethacrynic acid (Etacrynic acid sodium) sodium is a diuretic. Ethacrynic acid sodium is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid sodium is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid sodium also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid sodium has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice.
    Ethacrynic acid sodium
  • HY-107208R
    Procyanidol B4 (Standard)
    		Inhibitor
    Procyanidol B4 (Standard) is the analytical standard of Procyanidol B4 (HY-107208). This product is intended for research and analytical applications. Procyanidol B4 ((-)-Procyanidin B4) is an orally active polyphenol found in Q.gilva. Procyanidol B4 exerts antioxidant activity by scavenging DPPH (HY-112053) (IC50: 12.15 μM) and Nitro blue tetrazolium chloride (NBT) (HY-15925) (IC50: 8.67 μM). Procyanidol B4 exhibits anti-inflammatory activity by inhibiting the expression of COX-2 and IL-1β and iNOS .
    Procyanidol B4 (Standard)
  • HY-178487
    anti-TNBC agent-12
    		Inhibitor
    anti-TNBC agent-12 (Compound 23a) is a multi-target antitumor agent targeting HDAC6 (IC50=30.3 nM), DNA, and inducing nitric oxide (NO) release. anti-TNBC agent-12 induces tumor cell apoptosis and G2/M phase cell cycle arrest. anti-TNBC agent-12 is promising for research of triple-negative breast cancer (TNBC).
    anti-TNBC agent-12
  • HY-145869
    Anti-inflammatory agent 12
    		Inhibitor
    Anti-inflammatory agent 12 (Compound 2) is a pentacyclic triterpene compound. Anti-inflammatory agent 12 shows a significant bias in the LPS-induced inflammatory response with an IIC50 value of 2.22 μM. Anti-inflammatory agent 12 has the potential for the research of inflammation disease.
    Anti-inflammatory agent 12
  • HY-N15508
    Harzianoside B
    		Inhibitor
    Harzianoside B is a diterpene aminoglycoside compound discovered from Trichoderma sp. SCSIOW21. Harzianoside B has the activity of inhibiting the production of NO. In the experiment with macrophage RAW 264.7 cells, its IC50 value is close to the maximum tested concentration of 100 µM. It can be used in the research of the anti-inflammatory field.
    Harzianoside B
  • HY-N11945
    Schiarisanrin A
    		Inhibitor
    Schiarisanrin A (Kadsulignan J) is a lignan with inhibitory activity on NO production. Schiarisanrin A inhibits NO production in BV-2 cells with an IC50 of 9.6 μM.
    Schiarisanrin A
  • HY-P11502
    COG112
    		Inhibitor
    COG112 is an antennapedia-linked apoE-mimetic peptide. COG112 attenuates induction of NO production, inhibits CXC chemokines KC and MIP-2. COG112 reduces nuclear translocation of NF-κB. COG112 inhibits phosphorylation of IκB-α and prevents the degradation of IκB-α. COG112 inhibits the inflammatory response to Citrobacter rodentium .
    COG112
  • HY-N17761
    Tetrandrine 2'-N-α-oxide
    		Inhibitor
    Tetrandrine 2'-N-α-oxide (compound 13) is a bisbenzylisoquinoline alkaloid anti-inflammatory agent that can be isolated from the roots of Stephania tetrandra. Tetrandrine 2'-N-α-oxide may be used in research related to inflammatory diseases.
    Tetrandrine 2'-N-α-oxide
  • HY-N18025
    Kaempferol 3-O-(2G-glucosylrutinoside)-7-O-glucoside
    		Inhibitor
    Kaempferol 3-O-(2G-glucosylrutinoside)-7-O-glucoside is an anti-inflammatory agent. Kaempferol 3-O-(2G-glucosylrutinoside)-7-O-glucoside exerts significant anti-inflammatory effects in LPS (HY-D1056)-induced RAW 264.7 macrophages by inhibiting the NF-κB, MAPK and Akt signaling pathways, thereby reducing the production of inflammatory mediators (NO, PGE2) and pro-inflammatory cytokines (TNF-α, IL-1β, IL-6).
    Kaempferol 3-O-(2G-glucosylrutinoside)-7-O-glucoside
  • HY-N3226
    Myricananin A
    		Inhibitor
    Myricananin A is a colorless needle that has inhibitory effect on iNOS.
    Myricananin A
  • HY-N0455C
    L-Arginine arginine
    		Activator
    L-Arginine arginine is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis.
    L-Arginine arginine
  • HY-129138R
    Cyanidin 3,5-diglucoside chloride (Standard)
    		Inhibitor
    Cyanidin 3,5-diglucoside (chloride) (Standard) is the analytical standard of Cyanidin 3,5-diglucoside (chloride) (HY-129138). This product is intended for research and analytical applications. Cyanidin 3,5-diglucoside chloride is an anthocyanin. Cyanidin 3,5-diglucoside chloride inhibits inflammatory cytokines (IL-1α, IL-1β, and IL-6) expression and NO production. Cyanidin 3,5-diglucoside chloride inhibits the phosphorylation of STAT3, IκB, ERK, p38, and AKT. Cyanidin 3,5-diglucoside chloride inhibits high pressure-induced decrease in GLAST. Cyanidin 3,5-diglucoside chloride exerts anti-inflammatory and skin barrier modulating effects. Cyanidin 3,5-diglucoside chloride can be used in retinal research.
    Cyanidin 3,5-diglucoside chloride (Standard)
  • HY-N3246
    Morachalcone A
    		Inhibitor
    Morachalcone A is a naturally-occurring aromatase inhibitor (IC50=4.6 mM). Morachalcone A is also a plants metabolite with potential anti-inflammatory and anticancer activity. Morachalcone A inhibits Lipopolysaccharide (HY-D1056)-induced nitric oxide production.
    Morachalcone A
  • HY-N10865
    Chloranthalactone E
    		Inhibitor
    Chloranthalactone E (compound 6), a labdane diterpene, can be isolated from the aerial parts of Chloranthus serratus. Chloranthalactone E inhibits NO production in LPS-activated RAW 264.7 macrophages.
    Chloranthalactone E
  • HY-19392
    LA-419
    LA-419 is an orally active nitric oxide (NO) donor. LA-419 can significantly reduce the amount of fecal worm eggs excreted, shorten the duration of egg excretion, and also decrease the number of larvae in the lungs and the number of parasitic females in the intestines in mice infected with S. venezuelensis. LA-419 can reduce the formation of atherosclerosis in apolipoprotein E-deficient mice. LA-419 can be used for the researches of infection and cardiovascular disease.
    LA-419
Cat. No. Product Name / Synonyms Application Reactivity
NO Synthase Isoform Comparison

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